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KMID : 0624620120450090538
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BMB Reports
2012 Volume.45 No. 9 p.538 ~ p.543
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Differential expression of cell surface markers in response to 2,4-dinitrofluorobenzene in RAW 264.7 and primary immune cells
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Kim Dong-Bum
Park Min-Chul
Park Byoung-Kwon
Kwon Sang-Hoon
Choi Joon-Ho
Kim Hyun-Jong
Choi Soo-Young
Park Jin-Seu
Lee Young-Hee
Kwon Hyung-Joo
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Abstract
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We evaluated the expression of the costimulatory molecules CD80 and CD83 and major histocompatibility (MHC) class II induced by 2,4-dinitrofluorobenzene (DNFB) in the RAW 264.7macrophage cell line. In contrast to the previously reported effect of DNFB on dendritic cells, CD86 expression did not change. Furthermore, we observed that the CD83 expression level transiently increased and then decreased. Induction of CD80 and MHC class II moleculeexpression and a decrease in CD83 expression by DNFB in vitro were also confirmed in splenocytes of BALB/c and NC/Nga mice. However, DNFB did not influence CD83 expression in peritoneal CD11b(+) cells from BALB/c or NC/Nga mice. Detailed in vivo experiments and further studies on the possible contribution of CD11b(+) cells to induce atopic dermatitis (AD) would be helpful to attain a better understanding of AD pathogenesis.
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KEYWORD
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Atopic dermatitis, Costimulatory molecules, DNFB, Macrophages, NC/Nga mice
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